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Potassium Carbonate → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine

HRID 2358048
Notes
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Reaction equation

HRID 2358048 reaction equation
[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:25][CH2:26][O:27][CH3:28]>C(#N)C>[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH2:25][CH2:26][O:27][CH3:28])[CH2:14][CH2:13]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 574480384-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine

Product 1

HCID 115297644-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-piperidine (0.53 g, 1.64 mmol), acetonitrile (20 ml), potassium carbonate (0.45 g, 3.2 mmol), 1-bromo-2-methoxyethane (0.167 ml, 1.72 mmol). MS m/z (relative intensity, 70 eV) 315 (M+, 1), 271 (14), 270 (bp), 147 (10) 133 (9).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-00e1d975f95e4a289a8b01ab029e2f35
Source dataset
uspto-grants-2010_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07763639B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes