Hydrochloric Acid → 5-(1-Hydroxyhexadecylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Temperature

0 °C

To a solution of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid, 72 g) in dichloromethane (1 l) was added pyridine (81 ml). Then, palmitoyl chloride (150.7 g) was added thereto at 0° C. The mixture was stirred at 0° C. for 1 hour and for additional 2 hours at ambient temperature. The reaction mixture was diluted with chloroform (1 l), poured into ice water (1 l), acidified with dilute hydrochloric acid solution, and washed with water (500 ml×3). After drying over magnesium sulfate, the solvent was evaporated under reduced pressure to give 2,2-dimethyl-5-(1-hydroxyhexadecylidene)-1,3-dioxane-4,6-dione (200 g) as an oil.

1. customat 0° C
2. washwashed with water (500 ml×3)
3. dry with materialAfter drying over magnesium sulfate
4. customthe solvent was evaporated under reduced pressure

ORD record

ord-edcd776523f848a5af2621b84f6a06a4

Source dataset

uspto-grants-1987_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04643990