Ethylamine → N-(2-chloro-6-methyl-4-trifluoromethyl-3-pyridinyl)-2-ethylamino-3pyridinecarboxamide

HRID 2380230

Reaction equation

[CH2:1]([NH2:3])[CH3:2].Cl[C:5]1[C:10]([C:11]([NH:13][C:14]2[C:15]([Cl:25])=[N:16][C:17]([CH3:24])=[CH:18][C:19]=2[C:20]([F:23])([F:22])[F:21])=[O:12])=[CH:9][CH:8]=[CH:7][N:6]=1>C1(C)C(C)=CC=CC=1.C(OCC)(=O)C>[Cl:25][C:15]1[C:14]([NH:13][C:11]([C:10]2[C:5]([NH:3][CH2:1][CH3:2])=[N:6][CH:7]=[CH:8][CH:9]=2)=[O:12])=[C:19]([C:20]([F:23])([F:22])[F:21])[CH:18]=[C:17]([CH3:24])[N:16]=1

Participants

Conditions

Temperature: 160 °C

Procedure

Ethylamine (0.4 g) was added to a suspension of 1.3 g of 2-chloro-N-(2-chloro-6-methyl-4-trifluoromethyl-3-pyridinyl)-3-pyridinecarboxamide in 5 ml of xylene, and the resulting mixture heated in a pressure tube for 30 min. at 160° C. The cooled mixture was diluted with ethyl acetate, washed, dried, and concentrated. Column chromatography over silica gel (ethyl acetate/hexane, 1:1) gave 0.5 g of the title compound.

Workup

washwashed
customdried
concentrationconcentrated

Sources & evidence

ORD record: ord-6326097ba79e47bc84672e82f13d9fbb
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05366972

Linked notes

Loading…