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Hydrochloric Acid → HCID 178441102, compound

HRID 2381879
Notes
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Reaction equation

HRID 2381879 reaction equation
C([O:5][PH:6]([CH2:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:12]([OH:19])=[C:11]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:10]=1)=[O:7])CCC.Cl>[OH-].[Na+].C(O)(C)C>[C:15]([C:13]1[CH:14]=[C:9]([CH:10]=[C:11]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:12]=1[OH:19])[CH2:8][PH:6](=[O:5])[OH:7])([CH3:18])([CH3:17])[CH3:16]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178454798HCID 178454798, compound

Product 1

HCID 178441102HCID 178441102, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
100 °C

Procedure

17 grams (50 mmol) of (3,5-di-tert-butyl-4-hydroxy-benzyl)-phosphinic acid butyl ester in a mixture of 100 mL of 2.5 N sodium hydroxide solution and 10 mL of isopropanol is heated at 100° C. for 1 hour. The cooled reaction mixture is poured into a mixture of 25 mL of concentrated hydrochloric acid and 200 mL of ice. The product is extracted into 400 mL of chloroform and the chloroform layer is washed with 200 mL of water and then dried over sodium sulfate.

Workup

  1. customThe cooled reaction mixture
  2. extractionThe product is extracted into 400 mL of chloroform
  3. washthe chloroform layer is washed with 200 mL of water
  4. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-86c6a2bb928d4c4bad2245ac5d61a8aa
Source dataset
uspto-grants-2012_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08258253B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes