Methanol → Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate
Reaction equation
[C:1](Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[CH:9]=[C:10]([C:14]([C:17]([F:20])([F:19])[F:18])=[CH:15][N:16]=1)[C:11]([OH:13])=[O:12].CO>C(Cl)Cl.CN(C=O)C>[CH3:1][O:12][C:11](=[O:13])[C:10]1[C:14]([C:17]([F:20])([F:18])[F:19])=[CH:15][N:16]=[C:8]([Cl:7])[CH:9]=1Participants
6
Procedure
Oxalyl chloride (0.5 ml) was added to a solution of 2-chloro-5-(trifluoromethyl)isonicotinic acid (CAS Reg. No. 505084-58-2, 68 mg) in DCM (5 ml). DMF (1 drop) was added and the resulting mixture was stirred overnight at room temperature. Methanol (5 ml) was added and the mixture was concentrated to dryness. The crude product was used in the next step without further purification.
Workup
- concentrationthe mixture was concentrated to dryness
- customThe crude product was used in the next step without further purification
Sources & evidence
- ORD record
- ord-392ec75cd9614ab18dd961e4217e665d
- Source dataset
- uspto-grants-2012_09
- Patent number
- US08268820B2
Reaction notes
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