Allylamine → N-allyl-3-(N-vinylformamido)propionamide

HRID 2387

Reaction equation

HRID 2387 reaction equation
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10]CC)=O)[CH:4]=[O:5])=[CH2:2].[CH2:13]([NH2:16])[CH:14]=[CH2:15].C[O-].[Na+]>CO>[CH2:13]([NH:16][C:8](=[O:10])[CH2:7][CH2:6][N:3]([CH:1]=[CH2:2])[CH:4]=[O:5])[CH:14]=[CH2:15]

Participants

5

Reactant 3

HCID 7853AllylamineHCID 10942334Sodium MethoxideHCID 19690337ethyl 3-(N-vinylformamido)propionate

Product 1

HCID 19690345N-allyl-3-(N-vinylformamido)propionamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
90 °C

Procedure

A 100mL stainless steel high pressure reactor was charged with 17.1 grams (0.1 mol) of ethyl 3-(N-vinylformamido)propionate, 5.7 grams (0.1 mol) of allylamine and 0.15 gram of 25% sodium methoxide in methanol solution. The mixture was heated at 90° C. for 3 hours. Subsequent NMR analysis of the reaction mixture showed no conversion of the starting materials.

Sources & evidence

ORD record
ord-e627c68d0c1743fc987ec32e90fb2b64
Source dataset
uspto-grants-1998_03
Patent number
US05728878

Linked notes

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