Cesium carbonate → (3R,5S)-N-(2-[(2,3-Difluorobenzyl)thio]-6-methoxypyrimidin-4-yl)-3,5-dimethylpiperazine-1-sulfonamide

Reaction equation

C[C@H]1N[C@@H](C)CN(S(N)(=O)=O)C1.[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:21][S:22][C:23]1[N:28]=[C:27]([NH:29][S:30]([N:33]2[CH2:38][C@H:37]([CH3:39])[NH:36][C@H:35]([CH3:40])[CH2:34]2)(=[O:32])=[O:31])[CH:26]=[C:25]([O:41][C@H:42](C)CO)[N:24]=1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1.C(=O)([O-])[O-].[Cs+].[Cs+].ClC1C=C(OC)N=C(SCC2C=CC=C(F)C=2F)N=1.[Cl-].[NH4+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O.CCOC(C)=O>[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:21][S:22][C:23]1[N:28]=[C:27]([NH:29][S:30]([N:33]2[CH2:38][C@H:37]([CH3:39])[NH:36][C@H:35]([CH3:40])[CH2:34]2)(=[O:31])=[O:32])[CH:26]=[C:25]([O:41][CH3:42])[N:24]=1