Hydrochloric Acid → 4-(2-Propen-1-yloxy)cyclohexanone
Reaction equation
[CH2:1]([O:4][CH:5]1[CH2:14][CH2:13][C:8]2(OCC[O:9]2)[CH2:7][CH2:6]1)[CH:2]=[CH2:3].Cl.C(=O)([O-])O.[Na+]>CCOCC>[CH2:1]([O:4][CH:5]1[CH2:14][CH2:13][C:8](=[O:9])[CH2:7][CH2:6]1)[CH:2]=[CH2:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
19.8 g of compound (11) (0.1 mmole) were stirred for 2 hours at room temperature with 120 ml ether and 40 ml of 6N hydrochloric acid. The mixture was then neutralised with sodium hydrogen carbonate, extracted three times with ether, and the ether solution was dried over sodium sulphate. After removing the solvent by distillation, 15.2 g of crude product were obtained; the product was purified with 3:1 diisopropyl ether/n-hexane via a silica gel column.
Workup
- extractionextracted three times with ether
- dry with materialthe ether solution was dried over sodium sulphate
- customAfter removing the solvent
- distillationby distillation
Sources & evidence
- ORD record
- ord-dd41275c4d8046449c4bebbd28f00790
- Source dataset
- uspto-grants-1998_09
- Patent number
- US05801201
Reaction notes
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