Lithium Hydroxide → 3-Bromo-5-fluoro-4-methoxybenzoic acid
Reaction equation
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[C:6]([Br:13])[CH:5]=1.[OH-].[Li+]>C1COCC1.O>[Br:13][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([F:10])[C:7]=1[O:11][CH3:12])[C:3]([OH:14])=[O:2]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
5.8 g of the product obtained in step 2 were dissolved in 100 ml of a mixture of THF and water (9:1), 1.06 g (44.1 mmol) of lithium hydroxide were added and the mixture was stirred for 3 days. The solvent was evaporated and the residue was purified by preparative RP HPLC (water/ACN gradient). 2.9 g of the title compound were obtained.
Workup
- additionwere added
- customThe solvent was evaporated
- customthe residue was purified by preparative RP HPLC (water/ACN gradient)
Sources & evidence
- ORD record
- ord-33b1c970d7c24058a5f5ee0f01186d39
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08802720B2
Reaction notes
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