Piperidine → HCID 178515775, compound
Reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[N:12]1C=NC=N[CH:13]=1.N1CCCCC1>CO>[N:1]1[C:2]2[C:3](=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=2)[C:4]([OH:5])=[N:12][CH:13]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A mixture of 2-amino-5-hydroxybenzoic acid (19.64 g, 128 mmol), 1,3,5-triazine (15.6 g, 192 mmol), and piperidine (9 mL, 92.4 mmol) were heated to 60° C. in methanol (60 mL) for 2 hours. After cooling to 0° C., the mixture was filtered. The solid was washed with cold methanol and dried under high vacuum to provide the product (15 g, 72%) as white solid.
Workup
- filtrationthe mixture was filtered
- washThe solid was washed with cold methanol
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-135b540daf344f7390b3f86a9f694876
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648087B2
Reaction notes
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