Piperidine → HCID 178515775, compound

HRID 240563

Reaction equation

HRID 240563 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[N:12]1C=NC=N[CH:13]=1.N1CCCCC1>CO>[N:1]1[C:2]2[C:3](=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=2)[C:4]([OH:5])=[N:12][CH:13]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 92621,3,5-TriazineHCID 1645925-Hydroxyanthranilic acid

Product 1

HCID 178515775HCID 178515775, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 2-amino-5-hydroxybenzoic acid (19.64 g, 128 mmol), 1,3,5-triazine (15.6 g, 192 mmol), and piperidine (9 mL, 92.4 mmol) were heated to 60° C. in methanol (60 mL) for 2 hours. After cooling to 0° C., the mixture was filtered. The solid was washed with cold methanol and dried under high vacuum to provide the product (15 g, 72%) as white solid.

Workup

  1. filtrationthe mixture was filtered
  2. washThe solid was washed with cold methanol
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-135b540daf344f7390b3f86a9f694876
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Linked notes

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