Hydrochloric Acid → HCID 56848346, compound

Methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)-acetate (30.0 mg, 0.0786 mmol) was dissolved in 0.5 mL of methanol, and then 100 μL of 20% aqueous sodium hydroxide solution was added, and the reaction mixture was stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was diluted with 2 mL of ethyl acetate and neutralized by adding 200 μL of 10% aqueous hydrogen chloride solution. After removing water with anhydrous magnesium sulfate and filtering out the precipitate, the resulting solution was concentrated by distillation under reduced pressure and purified by column chromatography to obtain 26.4 mg (0.0718 mmol, 91%) of the desired compound.

1. customUpon completion of the reaction
2. customAfter removing water with anhydrous magnesium sulfate
3. filtrationfiltering out the precipitate
4. concentrationthe resulting solution was concentrated by distillation under reduced pressure
5. custompurified by column chromatography

ORD record

ord-c410c1933d6b437fb455963303b24484

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08809012B2