Triethylamine → HCID 136347703, compound
Reaction equation
[C:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)#[N:2].Cl.[NH2:12][OH:13].C(N(CC)CC)C>CO>[OH:13][N:12]=[C:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)[NH2:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Cyano uracil (2.0 g, 14.6 mmol) was suspended in methanol (50 mL), then hydroxylamine hydrochloride (1.4 g, 20.0 mmol) and triethylamine (2.8 mL, 20.0 mmol) were added and the mixture was heated to reflux overnight. The mixture was cooled to room temperature, the solid was collected by filtration, washed with methanol and dried to give the title compound as a pale yellow solid (1.8 g).
Workup
- temperaturethe mixture was heated
- temperatureto reflux overnight
- filtrationthe solid was collected by filtration
- washwashed with methanol
- customdried
Sources & evidence
- ORD record
- ord-847b5d1e0bfe4579a03ca873d9a9f2b9
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06821972B2
Reaction notes
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