Triethylamine → N'-Hydroxy-6-methyl-3-pyridazinecarboximidamide
Reaction equation
[C:1]([C:3]1[N:4]=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1)#[N:2].Cl.[NH2:11][OH:12].C(N(CC)CC)C>CO>[OH:12][N:11]=[C:1]([C:3]1[N:4]=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1)[NH2:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Cyano-6-methyl pyridazine (U.S. Pat. No. 5,914,319) (0.77 g, 6.4 mmol) was dissolved in methanol (20 mL), then hydroxylamine hydrochloride (0.66 g, 9.6 mmol) and triethylamine (1.3 mL, 9.6 mmol) were added and the mixture was stirred at room temperature overnight. The mixture was chilled in an ice-bath, then the solid was collected by filtration, washed with methanol and dried to give the title compound as a pale yellow solid (0.84 g).
Workup
- temperatureThe mixture was chilled in an ice-bath
- filtrationthe solid was collected by filtration
- washwashed with methanol
- customdried
Sources & evidence
- ORD record
- ord-cda37a2c2645428fb511e980785d23db
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06821972B2
Reaction notes
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