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4-Acetylpyridine → 1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-one

HRID 2418856
Notes
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Reaction equation

HRID 2418856 reaction equation
CC(=O)c1ccncc1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>CC(=O)c1ccnc(C(F)F)c1
ParticipantsConditionsSources & evidenceReaction notes

Participants

7

Reactant 2

HCID 142824-AcetylpyridineHCID 89600919CID 89600919

Product 1

HCID 585161081-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-oneYield 65%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-24043f9eb4064b3b8242f778d5cc6992
Source dataset
Minisci dataset from Roche
DOI
10.1021/ja211422g

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes