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4-Acetylpyridine → 1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-one

HRID 2418857
Notes
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Reaction equation

HRID 2418857 reaction equation
CC(=O)c1ccncc1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.CS(C)=O.O.O=C(O)C(F)(F)F>CC(=O)c1ccnc(C(F)F)c1.CC(=O)c1ccncc1C(F)F
ParticipantsConditionsSources & evidenceReaction notes

Participants

8

Reactant 2

HCID 142824-AcetylpyridineHCID 89600919CID 89600919

Product 2

HCID 585161081-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-oneYield 33%HCID 117778504Ethanone, 1-[3-(difluoromethyl)-4-pyridinyl]-Yield 22%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-6cecc8b4ad5f464a803f171a898f82ab
Source dataset
Minisci dataset from Roche
DOI
10.1021/ja211422g

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes