2-Mercaptobenzothiazole → 2-[(Difluoromethyl)sulfanyl]-1,3-benzothiazole

HRID 2418860Notes

Reaction equation

HRID 2418860 reaction equation
O=S(O)C(F)F.S=c1[nH]c2ccccc2s1.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>FC(F)Sc1nc2ccccc2s1

Participants

7

Reactant 2

HCID 6979932-MercaptobenzothiazoleHCID 89600919HCID 89600919, compound

Product 1

HCID 15223272-[(Difluoromethyl)sulfanyl]-1,3-benzothiazoleYield 61%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-1a22e1193ad948cb95e32e804572836c
Source dataset
Minisci dataset from Roche

Reaction notes

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