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3-Acetyl-5-bromopyridine → 1-(5-Bromo-6-isopropylpyridin-3-yl)ethan-1-one

HRID 2418897
Notes
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Reaction equation

HRID 2418897 reaction equation
CC(=O)c1cncc(Br)c1.CC(C)S(=O)O.[Zn]>CC(C)(C)OO.COc1ccccc1.O>CC(=O)c1cnc(C(C)C)c(Br)c1
ParticipantsConditionsSources & evidenceReaction notes

Participants

6

Reactant 2

HCID 8204233-Acetyl-5-bromopyridineHCID 117778686Propane-2-sulfinic acid;ZINC

Product 1

HCID 755298741-(5-Bromo-6-isopropylpyridin-3-yl)ethan-1-oneYield 41%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 7519AnisoleSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-326f55e501a44a0c9280dadd1dc989c1
Source dataset
Minisci dataset from Roche
DOI
10.1038/nature11680

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes