3,3-Diphenylpropylamine → Benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 24613

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[N:13]([C:14](OC3C=CC([N+]([O-])=O)=CC=3)=[O:15])[C:12]([O:26]C)=[N:11][C:10]([CH3:28])=[C:9]2[C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])[CH:5]=[CH:6][CH:7]=1.[C:39]1([CH:45]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH2:46][CH2:47][NH2:48])[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:9]([C:29]([O:31][CH2:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[O:30])=[C:10]([CH3:28])[NH:11][C:12](=[O:26])[N:13]2[C:14](=[O:15])[NH:48][CH2:47][CH2:46][CH:45]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)[CH:5]=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 60 °C

Procedure

10 ml of acetonitrile was added to a mixture of 200 mg (0.373 mmol) of 5-benzyl 1-(4-nitrophenyl) 6-(3-chlorophenyl)-2-methoxy-4-methyl-6H-pyrimidine-1,5-dicarboxylate and 78.9 mg (0.373 mmol) of 3,3-diphenylpropylamine, and they were stirred at 60° C. for 30 minutes. The solvent was evaporated under reduced pressure to obtain the title compound.

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-74147c16a95240d69ee024fbc23bdbd2
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06855716B2

Linked notes

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