Methyl iodide → HCID 20162056, compound
Reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].CI.[Cl:9][C:10]1([C:15]([OH:17])=[O:16])[CH2:12][C:11]1([Cl:14])[Cl:13]>CN(C)C(=O)C>[Cl:9][C:10]1([C:15]([O:17][CH3:1])=[O:16])[CH2:12][C:11]1([Cl:14])[Cl:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Potassium carbonate (4.14 grams) and methyl iodide (3.74 ml) were added to a solution of 1,2,2-trichlorocyclopropane carboxylic acid (5.68 grams) and N,N-dimethylacetamide (50 ml). The reaction mixture was stirred for approximately 20 hours and then filtered. Ethyl ether (250 ml) was added to the filtrate and the resultant mixture was washed, dried, and evaporated in vacuo to the desired product, methyl 1,2,2-trichlorocyclopropane carboxylate. Structure of the product was confirmed by NMR.
Workup
- filtrationfiltered
- additionEthyl ether (250 ml) was added to the filtrate
- washthe resultant mixture was washed
- customdried
- customevaporated in vacuo to the desired product, methyl 1,2,2-trichlorocyclopropane carboxylate
Sources & evidence
- ORD record
- ord-42f238a7495542028547310e3b96da5e
- Source dataset
- uspto-grants-1987_11
- Patent number
- US04704156
Reaction notes
Loading…