1-Hydroxybenzotriazole → HCID 178472721, compound

HRID 24755

Reaction equation

HRID 24755 reaction equation
C([C:4]1[CH:5]=[C:6]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][CH:9]=1)(O)=O.[CH2:28]([O:30][C:31](=[O:35])CNC)[CH3:29].CN([C:39]([O:43]N1N=NC2C=CC=CC1=2)=[N+:40]([CH3:42])[CH3:41])C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[CH2:28]([O:30][C:31]([CH2:42][N:40]([CH3:41])[C:39]([C:4]1[CH:5]=[C:6]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][CH:9]=1)=[O:43])=[O:35])[CH3:29]

Participants

7

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 95849Glycine, N-methyl-, ethyl esterHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 1785170813-[[(Z)-(2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]benzoic acid

Product 1

HCID 178472721HCID 178472721, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

Prepared analogously to Example 21 from (Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, sarcosine ethyl ester, TBTU, HOBt and triethylamine in DMF.

Sources & evidence

ORD record
ord-4fce04979bc14eab811e64766e7aea4a
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Linked notes

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