[H-].[Na+].[F:3][C:4]([F:12])([F:11])[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6].[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]Br.O>CN(C=O)C>[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][N:7]([CH:8]([CH3:10])[CH3:9])[C:5](=[O:6])[C:4]([F:12])([F:11])[F:3]
21 g (520 mmol) of 60% sodium hydride are suspended in 700 ml of anhydrous DMF under an inert atmosphere, and the mixture is cooled to 0° C. 40.5 g (260 mmol) of 2,2,2-trifluoro-N-isopropylacetamide are slowly added portionwise. After 15 minutes, 62 ml (520 mmol) of 1,4-dibromobutane are added. The reaction medium is then heated at 60° C. for 3 hours, and then cooled to room temperature, poured into 1 L of water and extracted with ethyl acetate. The organic phase is washed with water and dried, and the residue obtained is purified by distillation. A colorless oil is obtained (m=0.18 g, yield=24%).
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