4-Aminophenol → HCID 178500768, compound

Reaction equation

[CH:1]1[CH2:6][CH2:5][CH:4]([CH:7]=[CH:8][C:9](=[O:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH2:3][CH:2]=1.[OH:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1.[CH:24](OC(C)C)(C)C>C1C=CC=CC=1>[CH:1]1[CH2:6][CH2:5][CH:4]([CH:7]=[CH:8][C:9](=[O:15])[C:10](=[CH:24][NH:21][C:20]2[CH:22]=[CH:23][C:17]([OH:16])=[CH:18][CH:19]=2)[C:11]([O:13][CH3:14])=[O:12])[CH2:3][CH:2]=1

Participants

Procedure

In 20 ml benzene was dissolved 2.0 g of methyl 5-(cyclohexen-4-yl)-3-oxo-4-pentenoate, and 1.4 g of N,N-dimethylformamidodimethylacetal was added thereto. They were reacted at 70° C. for 1.5 hours. This reaction mixture was cooled to room temperature, and 1.2 g of p-hydroxyaniline was added thereto. They were reacted for 1.5 hours. After completion of the reaction, 50 ml of diisopropyl ether was added to the reaction mixture and the precipitated crystals were collected by filtration and washed with 20 ml of diisopropyl ether to obtain 2.1 g of methyl 5-(cyclohexen-4-yl)-2-(4-hydroxyphenylaminomethylene)-3-oxo-4-pentenoate having a melting point of 151°-153° C.