Methylamine → HCID 178483439, compound

HRID 25616

Reaction equation

[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=1)=[O:28].[CH3:40][NH2:41]>>[F:37][C:36]([F:39])([F:38])[C:33]1[CH:34]=[CH:35][C:30]([O:29][C:27](=[O:28])[N:2]([CH3:1])[C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:41][CH3:40])[CH2:7][CH2:8]2)=[CH:31][CH:32]=1

Participants

Reactant 4

HCID 6329Methylamine

HCID 6422Trifluoroacetic acid

HCID 159175974-(Trifluoromethyl)phenyl carbonochloridate

HCID 178484796HCID 178484796, compound

Product 1

HCID 178483439HCID 178483439, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-trifluoromethyl-phenyl chloroformate were reacted, followed by treatment with methylamine to give trans-Methyl-[4-(5-methylamino-pentyl)-cyclohexyl]-carbamic acid 4-trifluoromethyl-phenyl ester, MS: 401 (MH+).

Sources & evidence

ORD record: ord-526555117a2b4031930b54adf72a3654
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06858651B2

Linked notes

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