2-Pyrazoline → Pyrazole
Reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]=[N:2]1>[Br-].C([N+](CC)(CC)CC)C.C(O)C>[NH:2]1[CH2:3][CH2:4][CH:5]=[N:1]1.[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1Participants
5
Reactant 1
Product 2
Reagents, catalysts & solvents 2
Procedure
234 g of 2-pyrazoline and 64 g of tetraethylammonium bromide were dissolved in 3,000 g of ethanol and electrolyzed with 2 F/mol of 2-pyrazoline at a current density of 6.8 A/dm2 and 30° C. Working up as described in Example 1 gave 18.2 g of 2-pyrazoline and 129 g of pyrazole. This corresponds to a conversion of 92%, a yield of 57% and a selectivity of 62%.
Workup
- custom30° C
Sources & evidence
- ORD record
- ord-31d36474095d4c2bb8dc4d9f4c897248
- Source dataset
- uspto-grants-1987_10
- Patent number
- US04702803
Reaction notes
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