Methyl isothiocyanate → 1-Benzoyl-4-methyl-3-thiosemicarbazide
Reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][N:12]=[C:13]=[S:14]>C1COCC1>[C:1]([NH:9][NH:10][C:13]([NH:12][CH3:11])=[S:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of benzoic acid hydrazide (2.35 g, 1.73×10-2 mole) and THF (50 ml) was added a solution of methyl isothiocyanate (1.14 g, 1.56×10-2 mole) and THF (50 ml). The reaction was then refluxed for 2 hours before being cooled. The precipitate was collected by filtration and crystallized from ethanol, affording a colorless solid, Mp 199°-200° C.
Workup
- temperatureThe reaction was then refluxed for 2 hours
- temperaturebefore being cooled
- filtrationThe precipitate was collected by filtration
- customcrystallized from ethanol
- customaffording a colorless solid, Mp 199°-200° C.
Sources & evidence
- ORD record
- ord-11f6f64409204429a136ebf00d0e7e05
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05260450
Reaction notes
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