Isoquinoline → HCID 21425396, compound

HRID 258996

Reaction equation

HRID 258996 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[C:11]1([C:17]([CH:19]([Br:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1C=CC=CC=1>[Br-:26].[C:11]1([C:17]([CH:19]([C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][NH+:2]=2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:18])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 8405IsoquinolineHCID 1026302-Bromo-1,2-diphenylethan-1-one

Product 1

HCID 21425396HCID 21425396, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of isoquinoline(10 g) and desylbromide (10 g) in dry benzene (50 ml) was stirred at 40° for seven hours. The suspension was allowed to stand overnight, and the benzene solution decanted off. The solid was ground to a powder, washed well with ether, and dried. Yield 12.3 g (85%), m.p. 239°-241° (Found C 68.3; H 4.6; N 3.4, Required C 68.3; H 4.5; N 3.5).

Workup

  1. customthe benzene solution decanted off
  2. washwashed well with ether
  3. customdried

Sources & evidence

ORD record
ord-c0caa46ece104cd28f97510ceffa0466
Source dataset
uspto-grants-1977_07
Patent number
US04035499

Linked notes

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