1-Dodecanethiol → 1-(n-Dodecylthio)-3-isopropoxy-2-propanol

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

1. customformed by the addition of 50 mg
2. customAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
3. additionof water is added to the residue
4. extractionThe resultant aqueous mixture is extracted with ether
5. washthe ether extracts washed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated

ORD record

ord-1f4109b6444941dcb8d0392730d445b1

Source dataset

uspto-grants-1977_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04036974