Salicylic Acid → Choline salicylate sodium sulfite

Reaction equation

[C:1]([O:4][CH2:5][CH2:6][N+:7]([CH3:10])([CH3:9])[CH3:8])(=O)[OH:2].C(O)(=O)[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[OH:14].[S:21]([O-:24])([O-:23])=[O:22].[Na+:25].[Na+]>>[S:21]([O-:24])([O-:23])=[O:22].[Na+:25].[C:1]([O:4][CH2:5][CH2:6][N+:7]([CH3:10])([CH3:9])[CH3:8])(=[O:2])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[OH:14]

Participants

Reactant 3

HCID 338Salicylic Acid

HCID 24437Sodium Sulfite

HCID 23295436Choline carbonate

Product 1

HCID 67948796Choline salicylate sodium sulfite

Procedure

To an aqueous solution containing 28.5 grams of choline carbonate is added 13.8 grams of salicylic acid and 12.6 grams of sodium sulfite. The mixture is stirred until complete solution is achieved and the ebullition of gases cease. The solution of choline salicylate sodium sulfite thus formed is sufficiently pure to be used for further pharmaceutical manufacture. The compound choline salicylate sodium sulfite may be obtained by removing the solvent under high vacuum with the aid of gentle warming. The compound is a colorless crystal, that is highly hygroscopic, rapidly absorbing water on exposure to the atmosphere. An 0.1 molar solution of choline salicylate sodium sulfite has a specific electrical conductivity of 8.16× 10-3.