Water → 1-Amino-p-methoxyphenylmethanephosphonous acid

HRID 25983

Reaction equation

HRID 25983 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=O)=[CH:7][CH:8]=1.[PH2:11]([O-:13])=[O:12].[NH4+:14].O>C1(C)C(C)=CC=CC=1>[NH2:14][C:6]1([CH2:9][P:11]([OH:13])[OH:12])[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH2:7]1

Participants

5

Reactant 3

HCID 962WaterHCID 312444-MethoxybenzaldehydeHCID 178418291HCID 178418291, compound

Product 1

HCID 867364411-Amino-p-methoxyphenylmethanephosphonous acid

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent2×

Procedure

A mixture of 13.6 parts anisaldehyde and 8.3 parts ammonium hypophosphite in 100 parts xylene was refluxed with water separation. The xylene was cooled, decanted and the residue boiled with ethanol to give a white solid. Filtration gave DL-1-amino-p-methoxyphenylmethanephosphonous acid, melting point 239°-241° (dec.).

Workup

  1. customdecanted
  2. customto give a white solid
  3. filtrationFiltration

Sources & evidence

ORD record
ord-24e4c99b0b07489a91a8b31e14f959c8
Source dataset
uspto-grants-1979_04
Patent number
US04147780

Linked notes

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