Hydrochloric Acid → 4-(2-Thienyl)-4-oxobutyric acid oxime
Reaction equation
Cl.[NH2:2][OH:3].[OH-].[Na+].[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15].Cl>O>[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11](=[O:17])[CH2:12][CH2:13][C:14](=[N:2][OH:3])[OH:15]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 22.6 g. of hydroxylamine hydrochloride and 26 g. of NaOH in 300 ml. of water is stirred and 30 g. of 4-(2-thienyl)-4-oxobutyric acid is added to afford a clear yellow solution. The mixture is stirred for two hours at room temperature and acidified with 3N HCl to pH 2 to give a white precipitate. After stirring an additional half hour, the mixture is cooled in ice and filtered. The filter cake is washed with water and dried to afford the title compound, m.p. 133°-138° C.
Workup
- additionA mixture of 22.6 g
- customto afford a clear yellow solution
- customto give a white precipitate
- stirringAfter stirring an additional half hour
- temperaturethe mixture is cooled in ice
- filtrationfiltered
- washThe filter cake is washed with water
- customdried
Sources & evidence
- ORD record
- ord-0b5b7ffc77e843b4b9ffff6d8d6fc71c
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04154740
Reaction notes
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