Hydrochloric Acid → 2-nitro-7-dimethylamino-6,7-dihydro [5H] benzocycloheptene hydrochloride

HRID 262533

Reaction equation

HRID 262533 reaction equation
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]=[CH:11][C:12](=O)[C:6]=2[CH:5]=1)([O-:3])=[O:2].[CH3:16][NH:17][CH3:18].[ClH:19]>C(OCC)(=O)C>[ClH:19].[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]([N:17]([CH3:18])[CH3:16])[CH:11]=[CH:12][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 200947328,9-dihydro-3-nitro-5H-benzocyclohepten-5-one

Product 1

HCID 867365362-nitro-7-dimethylamino-6,7-dihydro [5H] benzocycloheptene hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Using the procedure of Example 1, 3-nitro-8,9-dihydro [5H] benzocycloheptene-5-one and dimethylamine were reacted to obtain a non-salified product which was treated in ethyl acetate with a solution of ethyl acetate saturated with gaseous hydrogen chloride to obtain a product which was crystallized from isopropanol to obtain 2-nitro-7-dimethylamino-6,7-dihydro [5H] benzocycloheptene hydrochloride melting at 202° C.

Workup

  1. customwere reacted
  2. customto obtain a non-salified product which
  3. customto obtain a product which
  4. customwas crystallized from isopropanol

Sources & evidence

ORD record
ord-90242655c5d1464691f6d4744eae6f66
Source dataset
uspto-grants-1979_05
Patent number
US04154852

Linked notes

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