Hydrochloric Acid → D-Galactosamine

HRID 263929

Reaction equation

HRID 263929 reaction equation
Cl.[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].Cl>O.CS(C)=O>[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 2723866D-(+)-Galactosamine hydrochloride2×

Product 1

HCID 24154D-Galactosamine

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

D-Galactosamine hydrochloride (hereinbelow abbreviated as D-galN, manufactured by Nakarai Tesque) and LPS were dissolved in water at final concentrations of 75 mg/ml and 0.1 or 0.2 μg/ml, respectively. Furthermore, the hydrochloride of Compound No. 33 in Test Example 1 was dissolved in a 5% dimethylsulfoxide-10% Nikkol (Nippon Surfactant Kogyo) solution at the final concentrations of 0, 0.25, 0.5 and 1 mg/ml, respectively.

Sources & evidence

ORD record
ord-a5c41b71e75742898fada5e067840dde
Source dataset
uspto-grants-1997_07
Patent number
US05646154

Linked notes

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