Cytidine → HCID 22874746, compound

HRID 264741

Reaction equation

HRID 264741 reaction equation
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[H-].[Na+].Br[CH2:21][CH2:22][CH3:23]>CN(C=O)C>[CH2:21]([O:3][C@@H:2]1[C@H:4]([OH:5])[C@@H:6]([CH2:7][OH:8])[O:9][C@H:1]1[N:10]1[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]1=[O:12])[CH2:22][CH3:23]

Participants

5

Reactant 3

HCID 6175CytidineHCID 78401-BromopropaneHCID 24758Sodium hydride

Product 1

HCID 22874746HCID 22874746, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Cytidine (16.5 g, 0.068 mol) was treated with sodium hydride (4.5 g) and bromopropane (15 ml) in DMF (150 ml) at room temperature for three days. The resulting reaction mixture was used directly in the next step (see Example 83).

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-ebe1e5446f864986a5d6bd5adfda59ed
Source dataset
uspto-grants-1997_07
Patent number
US05646265

Linked notes

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