Cytidine → 2'-O-Propylcytidine
Reaction equation
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[H-].[Na+].Br[CH2:21][CH2:22][CH3:23]>CN(C=O)C>[CH2:21]([O:3][C@@H:2]1[C@H:4]([OH:5])[C@@H:6]([CH2:7][OH:8])[O:9][C@H:1]1[N:10]1[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]1=[O:12])[CH2:22][CH3:23]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Cytidine (16.5 g, 0.068 mol) was treated with sodium hydride (4.5 g) and bromopropane (15 ml) in DMF (150 ml) at room temperature for three days. The resulting reaction mixture was used directly in the next step (see Example 83).
Workup
- customThe resulting reaction mixture
Sources & evidence
- ORD record
- ord-ebe1e5446f864986a5d6bd5adfda59ed
- Source dataset
- uspto-grants-1997_07
- Patent number
- US05646265
Reaction notes
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