Potassium Carbonate → 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone

HRID 26545

Reaction equation

HRID 26545 reaction equation
Cl.[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 51199Nafimidone monohydrochloride

Product 1

HCID 512002-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-(2-Naphthoylmethyl)imidazole hydrochloride (1.0 g.) suspended in 50 ml. of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-(2-naphthoylmethyl)imidazole.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-db5c8d01e01c4b6882b725e1358bba66
Source dataset
uspto-grants-1979_04
Patent number
US04150153

Linked notes

Loading…