Hydrochloric Acid → Piperazine-1-carboxamide Hydrochloride

HRID 267148

Reaction equation

HRID 267148 reaction equation
[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[ClH:10]>C(OCC)(=O)C>[ClH:10].[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2581921-Piperazinecarboxamide

Product 1

HCID 2769700Piperazine-1-carboxamide Hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.01 g of 1-[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-4-(tert.butoxycarbonyl)-N-tert.butyl-2(R or S)-piperazinecarboxamide (isomer B) was treated with hydrogen chloride in ethyl acetate as described in Example 97 to give 0.007 g of 1-[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-2(R or S)-piperazinecarboxamide hydrochloride as a very hygroscopic solid; MS: m/e 597 [M+H]+.

Sources & evidence

ORD record
ord-7789e615d386489198a3a88ff6c88196
Source dataset
uspto-grants-1997_07
Patent number
US05652369

Linked notes

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