Potassium Carbonate → HCID 21435679, compound

HRID 268046

Reaction equation

HRID 268046 reaction equation
[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:4]=1[NH2:5])[CH3:2].Cl[CH2:12][CH:13]1[O:17][CH2:16][CH2:15][O:14]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:14]1[CH2:15][CH2:16][O:17][CH:13]1[CH2:12][NH:5][C:4]1[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:3]=1[CH2:1][CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 324852-Ethyl-6-methylanilineHCID 757272-(Chloromethyl)-1,3-dioxolane

Product 1

HCID 21435679HCID 21435679, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Ethyl-6-methylaniline (70 grams), 2-chloromethyl-1,3-dioxolane (30 grams), potassium carbonate (38 grams) and dimethylformamide (50 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux for a period of about 24 hours. After this time the mixture was filtered and distilled to yield the desired product N-(1,3-dioxolan-2-ylmethyl)-2-ethyl-6-methylaniline.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux for a period of about 24 hours
  5. filtrationAfter this time the mixture was filtered
  6. distillationdistilled

Sources & evidence

ORD record
ord-f766387d9da6484f9e3a7c4a6a0b5b59
Source dataset
uspto-grants-1976_03
Patent number
US03946044

Linked notes

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