Diacetone Alcohol → HCID 85439537, compound

HRID 270729

Reaction equation

HRID 270729 reaction equation
[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=O)[CH3:5].Cl.[NH2:10][OH:11].C(=O)(O)[O-].[Na+]>O>[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=[N:10][OH:11])[CH3:5]

Participants

5

Reactant 3

HCID 31256Diacetone AlcoholHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 85439537HCID 85439537, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-hydroxy-4-methyl-2-pentanone (10.0 g, 85.7 mmole) and hydroxylamine hydrochloride (22.17 g, 343 mmole) in 90 ml of water was stirred vigorously at room temperature. To this solution was added slowly over a period of an hour solid sodium bicarbonate (26.8 g, 343 mmole). After 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml), dried (MgSO4) and evaporated under reduced pressure, to give the product as an oil. Yield 11.2 g

Workup

  1. extractionAfter 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-5ea092ec175b430aaa850965a685d7f9
Source dataset
uspto-grants-2008_11
Patent number
US07449581B2

Linked notes

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