Hydrochloric Acid → Diphosphoric acid, compd. with piperazine (1:1)

HRID 270753

Reaction equation

HRID 270753 reaction equation
[O-:1][P:2]([O:5][P:6]([O-:9])([O-:8])=[O:7])(=[O:4])[O-:3].[Na+].[Na+].[Na+].[Na+].Cl.[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>O>[OH:3][P:2]([O:5][P:6]([OH:9])([OH:8])=[O:7])(=[O:1])[OH:4].[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4837PiperazineHCID 24403Tetrasodium Pyrophosphate

Product 1

HCID 21989140Diphosphoric acid, compd. with piperazine (1:1)Yield 46%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
10 °C

Procedure

In 300 g of water was dispersed 0.5 mol of sodium pyrophosphate. The dispersion was cooled to 10° C., and 1 mol of hydrochloric acid was added thereto. To the dispersion was added 0.5 mol of piperazine (purity: 97%) dissolved in 800 g of water at 20° C. or lower, whereupon a white solid precipitated. The reaction system was stirred at 10° C. for 3 hours. The white solid was collected by filtration and washed with water. To the filtrate was added 300 g of methanol, and the thus precipitated white solid was collected by filtration and washed with methanol and water. The combined white solid was dried to give 0.23 mol of piperazine pyrophosphate as a white powder.

Workup

  1. customlower, whereupon a white solid precipitated
  2. filtrationThe white solid was collected by filtration
  3. washwashed with water
  4. additionTo the filtrate was added 300 g of methanol
  5. filtrationthe thus precipitated white solid was collected by filtration
  6. washwashed with methanol and water
  7. customThe combined white solid was dried

Sources & evidence

ORD record
ord-16e1e9eee7ef496084f3b545b516fbda
Source dataset
uspto-grants-2008_11
Patent number
US07449577B2

Linked notes

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