Hydrochloric Acid → 3-(Dimethylamino)-1-(furan-2-yl)propan-1-one--hydrogen chloride (1/1)
Reaction equation
[C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].[ClH:9].[CH3:10][NH:11][CH3:12].[CH2:13]=O.Cl>C(O)C>[ClH:9].[CH3:10][N:11]([CH2:13][CH2:2][C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:3])[CH3:12]Participants
6
Procedure
2-Acetylfuran (13.8 g), dimethylamine hydrochloride (13.3 g), paraformaldehyde (5.0 g) and ethanol (80 ml) acidified with concentrated HCl (1.0 ml) were stirred. Part of this mixture (27 ml) was pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;) and the hot product collected in an ice-water cooled flask, to afford pale yellow crystals m.p. 172.5°-173° C. (cf lit.10 m.p. 173°-4° C.) in 13% yield.
Workup
- customwas pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;)
- customthe hot product collected in an ice-water cooled flask
Sources & evidence
- ORD record
- ord-46302bb0417e4d80803efc7bded4318f
- Source dataset
- uspto-grants-1995_02
- Patent number
- US05387397
Reaction notes
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