1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene → 2-Fluoro-3,4-dimethoxybenzyl acetate

HRID 274489

Reaction equation

HRID 274489 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([O:11][CH3:12])[C:4]=1[F:13].[C:14]([O-:17])(=[O:16])[CH3:15].[K+]>CN(C)C=O>[C:14]([O:17][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([O:11][CH3:12])[C:4]=1[F:13])(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 2374111-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzeneHCID 517044Potassium Acetate

Product 1

HCID 536894592-Fluoro-3,4-dimethoxybenzyl acetate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.5 g of α-chloro-2-fluoro-3,4-dimethoxytoluene and 4.05 g of potassium acetate are stirred at 80° for 25 hours in 50 ml of dimethylformamide. The reaction mixture is subsequently poured into 150 ml of ice-water and extracted with ether. The ether phases are washed with sodium chloride solution, dried over sodium sulfate and evaporated. 2-fluoro-3,4-dimethoxybenzyl acetate is obtained as an oil.

Workup

  1. extractionextracted with ether
  2. washThe ether phases are washed with sodium chloride solution
  3. dry with materialdried over sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-f3f2f42fee6b48c9ac527ea8e89a40a3
Source dataset
uspto-grants-1995_02
Patent number
US05389653

Linked notes

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