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Triethylamine → HCID 53930965, compound

HRID 275547
Notes
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Reaction equation

HRID 275547 reaction equation
[Br:1]Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O[CH2:23][C:24]#[C:25][C:26]1[N:30]=[CH:29][N:28]([C:31]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:27]=1.C(N(CC)CC)C>ClCCl>[Br:1][CH2:23][C:24]#[C:25][C:26]1[N:30]=[CH:29][N:28]([C:31]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:27]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 24408BromineHCID 54249207HCID 54249207, compound

Product 1

HCID 53930965HCID 53930965, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent
3×

Conditions

Temperature
0 °C

Procedure

A solution of bromine (1.72 ml) in dry dichloromethane (10 ml) was added dropwise to a stirred, cooled (-5° C.), solution of triphenylphosphine (8.74 g) in dry dichloromethane (140 ml) whilst maintaining the temperature below 0° C. The solution was stirred for a further ten minutes at 0° C., then treated dropwise over one hour with a solution of the above alcohol (12.17 g) and triethylamine (4.64 ml) in dry dichloromethane (200 ml). After ten minutes, the mixture was evaporated under reduced pressure and the residue chromatographed on silica, using dichloromethane-ether (25:2) as eluant, to give 1-bromo-3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne (8.10 g, m.p. 181°-183° C. dec). NMR (CDCl3): δ4.1(2H,s), 7.05-7.35(15H,m), 7.95(1H,s). M/S: M+ 427,429.

Workup

  1. temperaturewhilst maintaining the temperature below 0° C
  2. waitAfter ten minutes
  3. customthe mixture was evaporated under reduced pressure
  4. customthe residue chromatographed on silica

Sources & evidence

ORD record
ord-7263f36c728b43cfb741ee78d66c9630
Source dataset
uspto-grants-1995_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05393732

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes