Triethylamine → HCID 18315818, compound

HRID 275942

Reaction equation

HRID 275942 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[CH2:5][CH2:4][NH:3]1.C(N(CC)CC)C.[CH3:21][C:22]1[C:23](Cl)=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]>CN(C)C=O>[CH3:21][C:22]1[C:23]([N:3]2[CH2:4][CH2:5][C:6]3[C:11](=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=3)[CH:2]2[CH3:1])=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 159400117-Methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 18315818HCID 18315818, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 1-methyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline (0.9 g, 5.1 mmol) and triethylamine(0.7 ml, 5.1 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine (0.8 g, 4.64 mmol) in dimethylformamide, 1.0 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 70.3%)

Sources & evidence

ORD record
ord-77bdd955311540bd908dc59913ce9e7b
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Linked notes

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