Hydrochloric Acid → 2-Aminomethyl-3'-hydroxybiphenyl hydrochloride
Reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=1)=O)(C)(C)C.[ClH:23]>CCOC(C)=O>[ClH:23].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-{N-(tert-butyloxycarbonyl)aminomethyl}-3′-hydroxybiphenyl from Step G (0.732 g, 2.45 mmol) in EtOAc (30 mL) at 0° C. was saturated with HCl gas. The mixture was aged at 0° C. for 5 min, then concentrated to dryness in vacuo to provide the titled compound as a white solid.
Workup
- customat 0° C.
- concentrationconcentrated to dryness in vacuo
Sources & evidence
- ORD record
- ord-923bc92bd2a44988abd75885b88e1df7
- Source dataset
- uspto-grants-2002_03
- Patent number
- US06358985B1
Reaction notes
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