Triethylamine → HCID 13478097, compound

HRID 280096

Reaction equation

HRID 280096 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:12][C:13]1[CH:28]=[CH:27][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1.C(N(CC)CC)C>C(O)(C)C>[F:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:2]3[N:11]=[CH:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[N:3]=3)[CH2:25][CH2:26]2)=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 740542-ChloroquinazolineHCID 18733961-[3-(4-Fluorophenoxy)propyl]piperazine

Product 1

HCID 13478097HCID 13478097, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2.5 g 2-Chloro-quinazoline, 3.8 g 1-[3-(4-fluorophenoxy)propyl]piperazine and 2.5 ml triethylamine in 15 ml isopropanol are stirred under reflux for 5 hours. The solvent is then evaporated in vacuo and the residue partitioned between water and methylene chloride. The organic phase is dried and evaporated. The residue is recrystallized from ethanol to yield the title compound, m.p. 126°-128° C.

Workup

  1. temperatureunder reflux for 5 hours
  2. customThe solvent is then evaporated in vacuo
  3. customthe residue partitioned between water and methylene chloride
  4. customThe organic phase is dried
  5. customevaporated
  6. customThe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-87f2de8023f14f53ac1b7ff2295fa747
Source dataset
uspto-grants-1986_05
Patent number
US04588725

Linked notes

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