Dichloromethane → (+/-)-2-hydroxy-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-1-one

HRID 282717

Reaction equation

HRID 282717 reaction equation
[CH3:82][CH2:83][O:84][C:85](=[O:86])[CH3:87].[CH:37]([N:38]([CH:39]([CH3:40])[CH3:41])[CH2:42][CH3:43])([CH3:44])[CH3:45].[Cl:79][CH2:80][Cl:81].[N:25]1([CH:31]2[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]2)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1.[OH:1][CH:2]([C:3](=[O:4])[OH:5])[CH2:6][c:7]1[cH:8][c:9]2[cH:10][n:11]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[n:12][c:13]2[c:14]([CH3:16])[cH:15]1.[P-:46]([F:47])([F:48])([F:49])([F:50])([F:51])[F:52].[n:53]1([O:54][P+:55]([N:56]2[CH2:57][CH2:58][CH2:59][CH2:60]2)([N:61]2[CH2:62][CH2:63][CH2:64][CH2:65]2)[N:66]2[CH2:67][CH2:68][CH2:69][CH2:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][c:76]2[n:77][n:78]1>>[OH:1][CH:2]([C:3](=[O:5])[N:34]1[CH2:33][CH2:32][CH:31]([N:25]2[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]2)[CH2:36][CH2:35]1)[CH2:6][c:7]1[cH:8][c:9]2[cH:10][n:11]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[n:12][c:13]2[c:14]([CH3:16])[cH:15]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 786071,4'-BipiperidineHCID 81531DiisopropylethylamineHCID 2724700Benzotriazol-1-yl-oxytripyrrolidinophosphoniumHCID 59424315(+/-)-2-Hydroxy-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)propanoic acid

Product 1

HCID 59424337(+/-)-2-hydroxy-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-1-one

Sources & evidence

ORD record
ord-f6374f039bab486a92e8d5419f24d916
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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