Ethyl Acetoacetate → 3-Oxo-n,n-dipropylbutanamide

Reaction equation

[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=[O:4].[CH2:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:11][CH3:12]>>[CH2:10]([N:13]([CH2:14][CH2:15][CH3:16])[C:1](=[O:7])[CH2:2][C:3](=[O:4])[CH3:5])[CH2:11][CH3:12]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 8902Dipropylamine

Product 1

HCID 2492073-Oxo-n,n-dipropylbutanamideYield 0.6%

Procedure

43.4 g (43.3 mol) of ethyl acetoacetate and 33.7 g (43.3 mol) of dipropylamine were treated as described in preparation 1. The crude oil was distilled at 86°-89° C./ 0.8 mmHg, to give 44.3 g of the title compound.

Workup

customas described in preparation 1
distillationThe crude oil was distilled at 86°-89° C./ 0.8 mmHg

Sources & evidence

ORD record: ord-9d861ba9b54b4ef8a7a1d9b237766965
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05731322

Reaction notes

Loading…