Diethyl Ether → 4-m-Tolyloxy-1H-indole-2-carboxylic acid ethyl ester

Reaction equation

[CH2:8]([CH3:9])[O:10][C:11](=[O:12])[c:13]1[nH:14][c:15]2[cH:16][cH:17][cH:18][c:19]([O:22][c:23]3[c:24]([NH2:30])[cH:25][cH:26][c:27]([CH3:29])[cH:28]3)[c:20]2[cH:21]1.[CH3:31][N:32]([CH3:33])[CH:34]=[O:35].[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[N:1]([O:2][C:3]([CH3:4])([CH3:5])[CH3:6])=[O:7]>>[CH2:8]([CH3:9])[O:10][C:11](=[O:12])[c:13]1[nH:14][c:15]2[cH:16][cH:17][cH:18][c:19]([O:22][c:23]3[cH:24][cH:25][cH:26][c:27]([CH3:29])[cH:28]3)[c:20]2[cH:21]1

Participants

Reactant 4

HCID 3283Diethyl Ether

HCID 6228Dimethylformamide

HCID 10906Tert-Butyl nitrite

HCID 668415234-(2-Amino-5-methyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester

Product 1

HCID 668417024-m-Tolyloxy-1H-indole-2-carboxylic acid ethyl ester

Sources & evidence

ORD record: ord-8dfa4f772635466b8557cc0873fcf307
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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