Tetrahydrofuran → 5-bromo-1-(2,6-dichlorophenyl)-7-(hydroxymethyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one
Reaction equation
[Al+3:35].[Br:1][c:2]1[c:3]2[c:8]([cH:9][c:10]([C:12](=[O:13])[O:14][CH3:15])[cH:11]1)[N:7]([c:16]1[c:17]([Cl:23])[cH:18][cH:19][cH:20][c:21]1[Cl:22])[C:6](=[O:24])[N:5]([CH2:25][c:26]1[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]1)[CH2:4]2.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[H-:34].[H-:37].[H-:38].[H-:39].[Li+:36]>>[Br:1][c:2]1[c:3]2[c:8]([cH:9][c:10]([CH2:12][OH:13])[cH:11]1)[N:7]([c:16]1[c:17]([Cl:23])[cH:18][cH:19][cH:20][c:21]1[Cl:22])[C:6](=[O:24])[N:5]([CH2:25][c:26]1[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]1)[CH2:4]2
