Dimethyl Sulfoxide → 4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine-5-carbaldehyde

Reaction equation

[C:5]([Cl:6])(=[O:7])[C:8]([Cl:9])=[O:10].[CH3:1][S:2]([CH3:3])=[O:4].[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH:11]1([c:14]2[n:15][c:16](-[c:22]3[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]3)[n:17][cH:18][c:19]2[CH2:20][OH:21])[CH2:12][CH2:13]1.[Cl:39][CH2:40][Cl:41]>>[CH:11]1([c:14]2[n:15][c:16](-[c:22]3[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]3)[n:17][cH:18][c:19]2[CH:20]=[O:21])[CH2:12][CH2:13]1

Participants

Reactant 5

HCID 679Dimethyl Sulfoxide

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 65578Oxalyl chloride

HCID 21935648[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol

Product 1

HCID 219356514-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine-5-carbaldehyde

Sources & evidence

ORD record: ord-ad5ed5f9844d43bdb301f20d359ca5fd
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…