Water → N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

HRID 302695

Reaction equation

HRID 302695 reaction equation
[CH:24]([N:25]([CH:26]([CH3:27])[CH3:28])[CH2:29][CH3:30])([CH3:31])[CH3:32].[CH:53]([Cl:54])([Cl:55])[Cl:56].[Cl:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([O:9][c:10]2[cH:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]23)[cH:8]1.[Cl:33][C:34]([Cl:35])([O:36][C:37]([O:38][C:39]([Cl:40])([Cl:41])[Cl:42])=[O:43])[Cl:44].[NH2:45][c:46]1[s:47][c:48]([CH2:51][CH3:52])[n:49][n:50]1.[OH2:57]>>[Cl:1][c:2]1[c:3]([NH:4][C:37](=[O:43])[NH:45][c:46]2[s:47][c:48]([CH2:51][CH3:52])[n:49][n:50]2)[cH:5][cH:6][c:7]([O:9][c:10]2[cH:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]23)[cH:8]1

Participants

7

Reactant 6

HCID 962WaterHCID 6212ChloroformHCID 264442-Amino-5-ethyl-1,3,4-thiadiazoleHCID 81531DiisopropylethylamineHCID 94429TriphosgeneHCID 112212234-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline

Product 1

HCID 23118598N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

Sources & evidence

ORD record
ord-6356b07309884de59b1d18fbfebc5c02
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

Loading…